2024-current.

L Ling, JC Crowley, ML Tan, JAMR Kunitake, AA Shimpi, RM Williams, LA Estroff, C. Fischbach, WR Zipfel. Assessing cellular metabolic dynamics with NAD (P) H fluorescence polarization imaging. bioRxiv, 2025.07. 28.667273

Suri M, Salimi Jazi F, Crowley JC, Park Y, Fu B, Chen P, Zipfel WR, Barstow B, Hanrath T. Spatially resolved charge-transfer kinetics at the quantum dot–microbe interface using fluorescence lifetime imaging microscopy. Proceedings of the National Academy of Sciences. 2025;122(12): e2407987122. doi: doi:10.1073/pnas.2407987122.

Grodner B, Shi H, Farchione O, Vill AC, Ntekas I, Diebold PJ, Wu DT, Chen C-Y, Kim DM, Zipfel WR, Brito IL, De Vlaminck I. Spatial mapping of mobile genetic elements and their bacterial hosts in complex microbiomes. Nature Microbiology. 2024;9(9):2262-77. doi: 10.1038/s41564-024-01735-5.

Huang Y, Kim H, Padilla Salas LA, Zipfel WR, Hur S-M, Ober CK. Nanoengineering Spikey Surfaces: Investigation of Reversible Organizational Control of Surface-Tethered Polypeptide Brushes. Langmuir. 2024;40(45):24045-61. doi: 10.1021/acs.langmuir.4c03345.

Versluis P, Graham TGW, Eng V, Ebenezer J, Darzacq X, Zipfel WR, Lis JT. Live-cell imaging of RNA Pol II and elongation factors distinguishes competing mechanisms of transcription regulation. Mol Cell. 2024 Aug 8;84(15):2856-2869.e9. doi: 10.1016/j.molcel.2024.07.009. PMID: 39121843; PMCID: PMC11486293.

Park S, Colville MJ, Paek JH, Shurer CR, Singh A, Secor EJ, Sailer CJ, Huang L-T, Kuo JC-H, Goudge MC, Su J, Kim M, DeLisa MP, Neelamegham S, Lammerding J, Zipfel WR, Fischbach C, Reesink HL, Paszek MJ. Immunoengineering can overcome the glycocalyx armour of cancer cells. Nature Materials. 2024;23(3):429-38. doi: 10.1038/s41563-024-01808-0.

Stuebler M, Manzer ZA, Liu H-Y, Miller J, Richter A, Krishnan S, Selivanovitch E, Banuna B, Jander G, Reimhult E, Zipfel WR, Roeder AHK, Piñeros MA, Daniel S. Plant Membrane-On-A-Chip: A Platform for Studying Plant Membrane Proteins and Lipids. ACS Applied Materials & Interfaces. 2024;16(16):20092-104. doi: 10.1021/acsami.3c18562.

Barkley, RJR, Crowley, JC, Brodrick, AJ, Zipfel, WR and JSL Parker. Fluorescent protein tags affect the condensation properties of a phase-separating viral protein. Molecular Biology of the Cell, 2024, E24-01-0013

Zhao L, Arias SL, Zipfel W, Brito IL, Yeo J. Coarse-grained modeling and dynamics tracking of nanoparticles diffusion in human gut mucus. International Journal of Biological Macromolecules. 2024; 267:131434. doi: https://doi.org/10.1016/j.ijbiomac.2024.131434.

2023

Roberts TC, Kushner M, Crowley JC, Ozer A, Wang J, Ray J, Lis JT, Zipfel WR. Nanoscale photobiotinylation, pulldown and sequencing of region-specific DNA from intact cells. bioRxiv. 2023:2023.12.04.569951. doi: 10.1101/2023.12.04.569951.

Williams RM, Bloom JC, Robertus CM, Recknagel AK, Putnam D, Schimenti JC, Zipfel WR. Practical strategies for robust and inexpensive imaging of aqueous-cleared tissues. Journal of Microscopy. 2023;291(3):237-47. doi: https://doi.org/10.1111/jmi.13213.

Tan ML, Jenkins-Johnston N, Huang S, Schutrum B, Vadhin S, Adhikari A, Williams RM, Zipfel WR, Lammerding J, Varner JD, Fischbach C. Endothelial cells metabolically regulate breast cancer invasion toward a microvessel. APL Bioengineering. 2023;7(4). doi: 10.1063/5.0171109.

Geng Y, Jena D, Fuchs GD, Zipfel WR, Rana F. Optical Dipole Structure and Orientation of GaN Defect Single-Photon Emitters. ACS Photonics. 2023;10(10):3723-9. doi: 10.1021/acsphotonics.3c00917.

2022

Colville M, Park S, Singh A, Paszek M, Zipfel WR. Azimuthal Beam Scanning Microscope Design and Implementation for Axial Localization with Scanning Angle Interference Microscopy. Methods Mol Biol. 2022; 2393:127-152. doi: 10.1007/978-1-0716-1803-5_7. PMID: 34837177.

Kailass, K, Sadovski, O, Zipfel, WR and AA. Beharry. Two-photon photodynamic therapy targeting cancers with low carboxylesterase 2 activity guided by ratiometric fluorescence.  J Med Chem. 2022 PMID: 35700557 DOI: 10.1021/acs.jmedchem.1c01965.

2021

Zipfel W, Xu C, Elson E, Maiti S. Memorial Viewpoint for Watt W. Webb: An Experimentalist's Experimentalist. J Phys Chem B. 2021 Mar 25;125(11):2793-2795. doi: 10.1021/acs.jpcb.1c01045. Epub 2021 Feb 24. PMID: 33622036.

Manzer ZA, Ghosh S, Jacobs ML, Krishnan S, Zipfel WR, Piñeros M, Kamat NP, Daniel S. Cell-Free Synthesis of a Transmembrane Mechanosensitive Channel Protein into a Hybrid-Supported Lipid Bilayer. ACS Appl Bio Mater. 2021 Apr 19;4(4):3101-3112. doi: 10.1021/acsabm.0c01482. Epub 2021 Mar 18. PMID: 35014398.

Digby EM, Ma T, Zipfel WR, Milstein JN, Beharry AA. Highly Potent Photoinactivation of Bacteria Using a Water-Soluble, Cell-Permeable, DNA-Binding Photosensitizer. ACS Infect Dis. 2021 Nov 12;7(11):3052-3061. doi: 10.1021/acsinfecdis.1c00313. Epub 2021 Oct 7. PMID: 34617443.

Jain P, Liu W, Zhu S, Chang CY, Melkonian J, Rockwell FE, Pauli D, Sun Y, Zipfel WR, Holbrook NM, Riha SJ, Gore MA, Stroock AD. A minimally disruptive method for measuring water potential in planta using hydrogel nanoreporters. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):e2008276118. doi:10.1073/pnas.2008276118. PMID: 34074748; PMCID: PMC8201978.

Illava G, Jayne R, Finke AD, Closs D, Zeng W, Milano SK, Huang Q, KriksunovI, Sidorenko P, Wise FW, Zipfel WR, Apker BA, Thorne RE. Integrated sample-handling and mounting system for fixed-target serial synchrotron crystallography. Acta Crystallogr D Struct Biol. 2021 May 1;77(Pt 5):628-644. doi: 10.1107/S2059798321001868. Epub 2021 Apr 19. PMID: 33950019;

2020

Singh A, Van Slyke AL, Sirenko M, Song A, Kammermeier PJ, and WR Zipfel.  Stoichiometric analysis of protein   complexes by cell fusion and single molecule imaging. Scientific Reports.  2020; 10(1):14866. doi: 10.1038/s41598-020-71630-6.

Kuo, J., M. C. Goudge, A. E. Metzloff, L.-T. Huang, M. J. Colville, S. Park, W. R. Zipfel and M. J. Paszek 2020. "Litmus-Body: A Molecularly Targeted Sensor for Cell-Surface pH Measurements." ACS Sensors.

Hu A, Keresztes I, MacMillan SN, Yang Y, Ding E, Zipfel WR, DiStasio RA, Jr., Babich JW, Wilson JJ.  Oxyaapa: A Picolinate-Based Ligand with Five Oxygen Donors that Strongly Chelates Lanthanides. Inorg Chem. (2020) 59(7):5116-32. Epub 2020/03/29. doi: 10.1021/acs.inorgchem.0c00372. PubMed PMID: 32216281.

Wang, J, Singh, A, Ozer, A., WR Zipfel. Fluorophore-labelled RNA aptamers to common protein tags as super resolution imaging reagents. bioRxiv 2020.02.27.968578;

Shi H, Shi Q, Grodner B, Lenz JS, Zipfel WR, Brito IL, De Vlaminck I. Highly multiplexed spatial mapping of microbial communities. Nature. 2020 Dec;588(7839):676-681. doi: 10.1038/s41586-020-2983-4. Epub 2020 Dec 2. PMID: 33268897; PMCID: PMC8050837.

2019

Colville M, Park, S, Zipfel, WR, Paszek, MJ “High-speed device synchronization in optical microscopy with an open-source hardware control platform” Sci Rep 9, 12188 (2019). https://doi.org/10.1038/s41598-019-48455-z

M. Kushner, J. Wang, A. Ozer, J. Ray, H. Lin, J. Lis, and WR. Zipfel, "Femto-Seq: A New Nonlinear Microcopy Approach for Elucidating Chromatin Structure at the Single Gene Level," in Biophotonics Congress: Optics in the Life Sciences Congress (2019) Optical Society of America.

2018

Holmes HL, Wilson B, Goerger JP, Silverberg JL, Cohen I, Zipfel WR, Fortier LA. Facilitated recruitment of mesenchymal stromal cells by bone marrow concentrate and platelet rich plasma. PLoS One. 2018 13(3): e0194567. doi: 10.1371/journal.pone.0194567. PMID: 29566102

Sierra C. Marker, Samantha N. MacMillan, Warren R. Zipfel, Zhi Li, Peter C. Ford, and Justin J. Wilson. Photoactivated in Vitro Anticancer Activity of Rhenium(I) Tricarbonyl Complexes Bearing Water-Soluble Phosphines, Inorganic Chemistry 2018 57(3): 1311-1331 DOI: 10.1021/acs.inorgchem.7b02747

Lidon P, Marker SC, Wilson JJ, Williams RM, Zipfel WR, Stroock AD.  Enhanced Oxygen Solubility in Metastable Water under Tension.  Langmuir. 2018 34(40):12017-12024. doi: 10.1021/acs.langmuir.8b02408. Epub 2018 Sep 28. PMID: 30221943

McCoy, MG, Wei, JM, Choi, S, Goerger, JP; Zipfel, W, Fischbach, C.  Collagen Fiber Orientation Regulates 3D Vascular Network Formation and Alignment.  ACS BIOMATERIALS SCIENCE & ENGINEERING. 4 (8): 2967-2976.  2018 DOI: 10.1021/acsbiomaterials.8b00384

2017

Michaudel Q, Chauvir, AT, Kottisch V, Supej MJ, Stawiasz KJ, Shen L, Zipfel WR, Abruna HD, Freed JH, Fors BP. Mechanistic Insight into the Photocontrolled Cationic Polymerization of Vinyl Ethers. Journal of the American Chemical Society. 2017;139(43):15530-8. doi: 10.1021/jacs.7b09539.

2016

Lukk T, Gillilan RE, Szebenyi, DM, Zipfel WR. A visible-light-excited fluorescence method for imaging protein crystals without added dyes. J Appl Crystallogr. 2016 49:234-240. PMID: 26937240

Migone FF, Cowan RG, Williams RM, Gorse KJ, Zipfel WR, Quirk SM. In vivo imaging reveals an essential role of vasoconstriction in rupture of the ovarian follicle at ovulation. PNAS, 2016. 113(8):2294-9. doi:10.1073/pnas.1512304113.

2015

Singh, A., J.D. McMullen, E.A. Doris, and W.R. Zipfel, Comparison of objective lenses for multiphoton microscopy in turbid samples. Biomed Opt Express, 2015. 6(8): p. 3113-27.

Sattarzadeh, A., R. Saberianfar, W.R. Zipfel, R. Menassa, and M.R. Hanson, Green to red photoconversion of GFP for protein tracking in vivo. Sci Rep, 2015. 5: p. 11771.

O'Dell, R.S., D.A. Cameron, W.R. Zipfel, and E.C. Olson, Reelin Prevents Apical Neurite Retraction during Terminal Translocation and Dendrite Initiation. J Neurosci, 2015. 35(30): p. 10659-74.

2014

Novakofski, K.D., R.M. Williams, L.A. Fortier, H.O. Mohammed, W.R. Zipfel, and L.J. Bonassar, Identification of cartilage injury using quantitative multiphoton microscopy. Osteoarthritis Cartilage, 2014. 22(2): p. 355-62.

Buckley, M.S., H. Kwak, W.R. Zipfel, and J.T. Lis, Kinetics of promoter Pol II on Hsp70 reveal stable pausing and key insights into its regulation. Genes & Development, 2014. 28(1): p. 14-19.

Penterman, S.J., A. Singh, W.R. Zipfel, and C.M.L. Watson, Anisometric Colloidal Fullerene Rod and Platelet Solvates with Enhanced Photoluminescence. Advanced Optical Materials, 2014. 2(11): p. 1024-1030.

2013

Migone, F.F., R.G. Cowan, R.M. Williams, W.R. Zipfel, and S.M. Quirk, Multiphoton microscopy as a tool to study ovarian vasculature in vivo. IntraVital, 2013. 2(1): p. e24334.

Byrnes, L.J., A. Singh, K. Szeto, N.M. Benvin, J.P. O'Donnell, W.R. Zipfel, and H. Sondermann, Structural basis for conformational switching and GTP loading of the large G protein atlastin. EMBO J, 2013. 32(3): p. 369-84.

Bu, P., K.-Y. Chen, J.H. Chen, L. Wang, J. Walters, Y.J. Shin, J.P. Goerger, J. Sun, M. Witherspoon, N. Rakhilin, J. Li, H. Yang, J. Milsom, S. Lee, W. Zipfel, M.M. Jin, Z.H. Guemues, S.M. Lipkin, and X. Shen, A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells. Cell Stem Cell, 2013. 12(5): p. 602-615.

2012

Choi, N.W., S.S. Verbridge, R.M. Williams, J. Chen, J.-Y. Kim, R. Schmehl, C.E. Farnum, W.R. Zipfel, C. Fischbach, and A.D. Stroock, Phosphorescent nanoparticles for quantitative measurements of oxygen profiles in vitro and in vivo. Biomaterials, 2012. 33(9): p. 2710-2722.

Degala, S., R. Williams, W. Zipfel, and L.J. Bonassar, Calcium signaling in response to fluid flow by chondrocytes in 3D alginate culture. Journal of Orthopaedic Research, 2012. 30(5): p. 793-799.

Jain, M., B.D. Robinson, D.S. Scherr, J. Sterling, M.-M. Lee, J. Wysock, M.A. Rubin, F.R. Maxfield, W.R. Zipfel, W.W. Webb, and S. Mukherjee, Multiphoton Microscopy in the Evaluation of Human Bladder Biopsies. Archives of Pathology & Laboratory Medicine, 2012. 136(5): p. 517-526.

Khan, I., R. Gillilan, I. Kriksunov, R. Williams, W.R. Zipfel, and U. Englich, Confocal microscopy on the beamline: novel three-dimensional imaging and sample positioning. Journal of Applied Crystallography, 2012. 45: p. 936-943.

O'Dell, R.S., C.J.M. Ustine, D.A. Cameron, S.M. Lawless, R.M. Williams, W.R. Zipfel, and E.C. Olson, Layer 6 cortical neurons require Reelin-Dab1 signaling for cellular orientation, Golgi deployment, and directed neurite growth into the marginal zone. 2012 Neural Dev 7:25. https://doi.org/10.1186/1749-8104-7-25.

Shui, B., A. Ozer, W. Zipfel, N. Sahu, A. Singh, J.T. Lis, H. Shi, and M.I. Kotlikoff, RNA aptamers that functionally interact with green fluorescent protein and its derivatives. Nucleic Acids Research, 2012. 40(5).

2011

McMullen, J.D., A.C. Kwan, R.M. Williams, and W.R. Zipfel, Enhancing collection efficiency in large field of view multiphoton microscopy. Journal of Microscopy, 2011. 241(2): p. 119-124.

Degala, S., W.R. Zipfel, and L.J. Bonassar, Chondrocyte calcium signaling in response to fluid flow is regulated by matrix adhesion in 3-D alginate scaffolds. Archives of Biochemistry and Biophysics, 2011. 505(1): p. 112-117.

Tewari, A.K., M.M. Shevchuk, J. Sterling, S. Grover, M. Herman, R. Yadav, K. Mudalair, A. Srivastava, M.A. Rubin, W.R. Zipfel, F.R. Maxfield, C. Xu, W.W. Webb, and S. Mukherjee, Multiphoton microscopy for structure identification in human prostate and periprostatic tissue: implications in prostate cancer surgery. BJU International, 2011. 108(9): p. 1421-1429.

Wang, Q., L.J. Byrnes, B. Shui, U.F. Roehrig, A. Singh, D.M. Chudakov, S. Lukyanov, W.R. Zipfel, M.I. Kotlikoff, and H. Sondermann, Molecular Mechanism of a Green-Shifted, pH-Dependent Red Fluorescent Protein mKate Variant. Plos One, 2011. 6(8).

2010

Dela Cruz, J.M., J.D. McMullen, R.M. Williams, and W.R. Zipfel, Feasibility of using multiphoton excited tissue autofluorescence for in vivo human histopathology. Biomedical Optics Express, 2010. 1(5): p. 1320-1330.

McMullen, J.D. and W.R. Zipfel, A multiphoton objective design with incorporated beam splitter for enhanced fluorescence collection. Optics Express, 2010. 18(6): p. 5390-5398.

Williams, R.M., A. Flesken-Nikitin, L.H. Ellenson, D.C. Connolly, T.C. Hamilton, A.Y. Nikitin, and W.R. Zipfel, Strategies for High-Resolution Imaging of Epithelial Ovarian Cancer by Laparoscopic Nonlinear Microscopy. Translational Oncology, 2010. 3(3): p. 181-194.

Zobeck, K.L., M.S. Buckley, W.R. Zipfel, and J.T. Lis, Recruitment Timing and Dynamics of Transcription Factors at the Hsp70 Loci in Living Cells. Molecular Cell, 2010. 40(6): p. 965-975.

Bowles, R.D., R.M. Williams, W.R. Zipfel, and L.J. Bonassar, Self-Assembly of Aligned Tissue-Engineered Annulus Fibrosus and Intervertebral Disc Composite Via Collagen Gel Contraction. Tissue Engineering Part A, 2010. 16(4): p. 1339-1348.

Kim, S.A., H. Sanabria, M.A. Digman, E. Gratton, P. Schwille, W.R. Zipfel, and M.N. Waxham, Quantifying Translational Mobility in Neurons: Comparison between Current Optical Techniques. Journal of Neuroscience, 2010. 30(49): p. 16409-16416.

2009

Jhaveri, S.J., J.D. McMullen, R. Sijbesma, L.-S. Tan, W. Zipfel, and C.K. Ober, Direct Three-Dimensional Microfabrication of Hydrogels via Two-Photon Lithography in Aqueous Solution. Chemistry of Materials, 2009. 21(10): p. 2003-2006.

Steidl, L., S.J. Jhaveri, R. Ayothi, J. Sha, J.D. McMullen, S.Y.C. Ng, W.R. Zipfel, R. Zentel, and C.K. Ober, Non-ionic photo-acid generators for applications in two-photon lithography. Journal of Materials Chemistry, 2009. 19(4): p. 505-513.

2008

Cheshire, A.M., B.E. Kerman, W.R. Zipfel, A.A. Spector, and D.J. Andrew, Kinetic and Mechanical Analysis of Live Tube Morphogenesis. Developmental Dynamics, 2008. 237(10): p. 2874-2888.

Park, H.Y., S.A. Kim, J. Korlach, E. Rhoades, L.W. Kwok, W.R. Zipfel, M.N. Waxham, W.W. Webb, and L. Pollack, Conformational changes of calmodulin upon Ca2+ binding studied with a microfluidic mixer. Proceedings of the National Academy of Sciences of the United States of America, 2008. 105(2): p. 542-547.

Rogart, J.N., J. Nagata, C.S. Loeser, R.D. Roorda, H. Aslanian, M.E. Robert, W.R. Zipfel, and M.H. Nathanson, Multiphoton imaging can be used for microscopic examination of intact human gastrointestinal mucosa ex vivo. Clinical Gastroenterology and Hepatology, 2008. 6(1): p. 95-101.

2007

Choi, J., A.A. Burns, R.M. Williams, Z. Zhou, A. Flesken-Nikitin, W.R. Zipfel, U. Wiesner, and A.Y. Nikitin, Core-shell silica nanoparticles as fluorescent labels for nanomedicine. Journal of Biomedical Optics, 2007. 12(6): p 064007-1 to 7.

Croix, C.S., W.R. Zipfel, and S.C. Watkins, Potential solutions for confocal imaging of living animals. Biotechniques, 2007. 43(1): p. 14-19.

Flesken-Nikitin, A., I. Toshkov, J. Naskar, K.M. Tyner, R.M. Williams, W.R. Zipfel, E.P. Giannelis, and A.Y. Nikitin, Toxicity and biomedical imaging of layered nanohybrids in the mouse. Toxicologic pathology, 2007. 35(6): p. 806-12.

Kloppenburg, P., W.R. Zipfel, W.W. Webb, and R.M. Harris-Warrick, Heterogeneous effects of dopamine on highly localized, voltage-induced Ca2+ accumulation in identified motoneurons. Journal of Neurophysiology, 2007. 98(5): p. 2910-2917.

Williams, R.M., W.R. Zipfel, M.L. Tinsley, and C.E. Farnum, Solute transport in growth plate cartilage: In vitro and in vivo. Biophysical Journal, 2007. 93(3): p. 1039-1050.

2006

Farnum, C.E., M. Lenox, W. Zipfel, W. Horton, and R. Williams, In vivo delivery of fluoresceinated dextrans to the murine growth plate: Imaging of three vascular routes by multiphoton microscopy. Anatomical Record Part a-Discoveries in Molecular Cellular and Evolutionary Biology, 2006. 288A(1): p. 91-103.

Ji, G.J., M. Feldman, R. Doran, W. Zipfel, and M.I. Kotlikoff, Ca2+-induced Ca2+ release through localized Ca2+ uncaging in smooth muscle. Journal of General Physiology, 2006. 127(3): p. 225-235.

Park, H.Y., X.Y. Qiu, E. Rhoades, J. Korlach, L.W. Kwok, W.R. Zipfel, W.W. Webb, and L. Pollack. Achieving uniform mixing in a microfluidic device: Hydrodynamic focusing prior to mixing. Analytical Chemistry, 2006. 78(13): p. 4465-4473.

Rizzo, M.A., G. Springer, K. Segawa, W.R. Zipfel, and D.W. Piston, Optimization of pairings and detection conditions for measurement of FRET between cyan and yellow fluorescent proteins. Microscopy and Microanalysis, 2006. 12(3): p. 238-254.

Tallini, Y.N., B. Shui, K.S. Greene, K.-Y. Deng, R. Doran, P.J. Fisher, W. Zipfel, and M.I. Kotlikoff, BAC transgenic mice express enhanced green fluorescent protein in central and peripheral cholinergic neurons. Physiological Genomics, 2006. 27(3): p. 391-397.

2005

Williams, R.M., W.R. Zipfel, and W.W. Webb, Interpreting second-harmonic generation images of collagen I fibrils. Biophysical Journal, 2005. 88(2): p. 1377-1386.

Yao, J., D.R. Larson, H.D. Vishwasrao, W.R. Zipfel, and W.W. Webb, Blinking and nonradiant dark fraction of water-soluble quantum dots in aqueous solution. PNAS, 2005. 102(40): p. 14284-14289.

Zhu, G.H., J. van Howe, M. Durst, W. Zipfel, and C. Xu, Simultaneous spatial and temporal focusing of femtosecond pulses. Optics Express, 2005. 13(6): p. 2153-2159.

2004

Atshaves, B.P., A.M. McIntosh, O.I. Lyuksyutova, W. Zipfel, W.W. Webb, and F. Schroeder, Liver fatty acid-binding protein gene ablation inhibits branched-chain fatty acid metabolism in cultured primary hepatocytes. Journal of Biological Chemistry, 2004. 279(30): p. 30954-30965.

Foquet, M., J. Korlach, W.R. Zipfel, W.W. Webb, and H.G. Craighead, Focal volume confinement by submicrometer-sized fluidic channels. Analytical Chemistry, 2004. 76(6): p. 1618-1626.

Kasischke, K.A., H.D. Vishwasrao, P.J. Fisher, W.R. Zipfel, and W.W. Webb, Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis. Science, 2004. 305(5680): p. 99-103.

Levene, M.J., D.A. Dombeck, R.M. Williams, J. Skoch, G.A. Hickey, K.A. Kasischke, R.P. Molloy, M. Ingelsson, E.A. Stern, J. Klucken, B.J. Bacskai, W.R. Zipfel, B.T. Hyman, and W.W. Webb, In vivo multiphoton microscopy of deep tissue with gradient index lenses. Multiphoton Microscopy in the Biomedical Sciences Iv, 2004. 5323: p. 291-296.

Stroh, M., W.R. Zipfel, R.M. Williams, S.C. Ma, W.W. Webb, and W.M. Saltzman, Multiphoton microscopy guides neurotrophin modification with poly(ethylene glycol) to enhance interstitial diffusion. Nature Materials, 2004. 3(7): p. 489-494.

2003

Zipfel, W.R., R.M. Williams, R. Christie, A.Y. Nikitin, B.T. Hyman, and W.W. Webb, Live tissue Intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation. Proceedings of the National Academy of Sciences of the United States of America, 2003. 100(12): p. 7075-7080.

Zipfel, W.R., R.M. Williams, and W.W. Webb, Nonlinear magic: multiphoton microscopy in the biosciences. Nature Biotechnology, 2003. 21(11): p. 1368-1376.

Maiti, S., J.B. Shear, R.M. Williams, W.R. Zipfel, and W.W. Webb, Measuring serotonin distribution in live cells with three-photon excitation. SPIE milestone series, 2003. 175: p. 524-526.

Brown, E.B., E.S. Wu, W. Zipfel, and W.W. Webb, Measurement of molecular diffusion in solution by multiphoton fluorescence photobleaching recovery. SPIE milestone series, 2003. 175: p. 271-283.

Xu, C., W. Zipfel, J.B. Shear, R.M. Williams, and W.W. Webb, Multiphoton fluorescence excitation: New spectral windows for biological nonlinear microscopy. SPIE milestone series, 2003. 175: p. 501-506.

Echevarria, W., M.F. Leite, M.T. Guerra, W.R. Zipfel, and M.H. Nathanson, Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Nature Cell Biology, 2003. 5(5): p. 440-446.

Ladewig, T., P. Kloppenburg, P.M. Lalley, W.R. Zipfel, W.W. Webb, and B.U. Keller, Spatial profiles of store-dependent calcium release in motoneurones of the nucleus hypoglossus from newborn mouse. Journal of Physiology-London, 2003. 547(3): p. 775-787.

Larson, D.R., W.R. Zipfel, R.M. Williams, S.W. Clark, M.P. Bruchez, F.W. Wise, and W.W. Webb, Water-soluble quantum dots for multiphoton fluorescence imaging in vivo. Science, 2003. 300(5624): p. 1434-1436.

Orth, R.N., J. Kameoka, W.R. Zipfel, B. Ilic, W.W. Webb, T.G. Clark, and H.G. Craighead. Creating biological membranes on the micron scale: Forming patterned lipid bilayers using a polymer lift-off technique. Biophysical Journal, 2003. 85(5): p. 3066-3073.

Stroh, M., W.R. Zipfel, R.M. Williams, W.W. Webb, and W.M. Saltzman.  Diffusion of nerve growth factor in rat striatum as determined by multiphoton microscopy. Biophysical Journal, 2003. 85(1): p. 581-588.

2002

Williams, R.M., W.R. Zipfel, and W.W. Webb, Multiphoton microscopy in biological research. Current Opinion in Chemical Biology, 2001. 5(5): p. 603-608.

Ouzounov, D.G., K.D. Moll, M.A. Foster, W.R. Zipfel, W.W. Webb, and A.L. Gaeta, Delivery of nanojoule femtosecond pulses through large-core micro-structured fibers. Optics Letters, 2002. 27(17): p. 1513-1515.

Bago, B., P.E. Pfeffer, W. Zipfel, P. Lammers, and Y. Shachar-Hill, Tracking metabolism and imaging transport in arbuscular mycorrhizal fungi. Metabolism and transport in AM fungi. Plant and Soil, 2002. 244(1-2): p. 189-197.

Bago, B., W. Zipfel, R.M. Williams, J. Jun, R. Arreola, P.J. Lammers, P.E. Pfeffer, and Y. Shachar-Hill, Translocation and utilization of fungal storage lipid in the arbuscular mycorrhizal symbiosis. Plant Physiology, 2002. 128(1): p. 108-124.

Foquet, M., J. Korlach, W. Zipfel, W.W. Webb, and H.G. Craighead, DNA fragment sizing by single molecule detection in submicrometer-sized closed fluidic channels. Analytical Chemistry, 2002. 74(6): p. 1415-1422.

Kloppenburg, P., B.R. Johnson, W.R. Zipfel, W.W. Webb, and R.M. Harris-Warrick, Multiple effects of dopamine on an identified motor neuron analyzed by electrophysiological and optical imaging techniques. Crustacean Nervous System, 2002: p. 204-216.

O'Neill, A.F., R.E. Hagar, W.R. Zipfel, M.H. Nathanson, and B.E. Ehrlich, Regulation of the type III InsP(3) receptor by InSP3 and calcium. Biochemical and Biophysical Research Communications, 2002. 294(3): p. 719-725.

Ouzounov, D.G., K.D. Moll, M.A. Foster, W.R. Zipfel, W.W. Webb, and A.L. Gaeta, Delivery of nanojoule femtosecond pulses through large-core microstructured fibers. Optics & Photonics News, 2002. 13(12): p. 27-28.

2001

Ouzounov, D., D. Homoelle, W. Zipfel, W.W. Webb, A.L. Gaeta, J.A. West, J.C. Fajardo, and K.W. Koch, Dispersion measurements of micro-structured fibers using femtosecond laser pulses. Optics Communications, 2001. 192(3): p. 219-223.

Christie, R.H., B.J. Bacskai, W.R. Zipfel, R.M. Williams, S.T. Kajdasz, W.W. Webb, and B.T. Hyman, Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy. Journal of Neuroscience, 2001. 21(3): p. 858-864.

2000

Zipfel, W., A new-age Hooke book. Nature Cell Biology, 2000. 2(12): p. 222.

Kloppenburg, P., W.R. Zipfel, W.W. Webb, and R.M. Harris-Warrick. Highly localized Ca2+ accumulation revealed by multiphoton microscopy in an identified motoneuron and its modulation by dopamine. Journal of Neuroscience, 2000. 20(7): p. 2523-2533.

1999

Shear, J.B., W.R. Zipfel, S. Maiti, and W.W. Webb, Mucosal Mast Cell Secretion Processes Imaged Using Three-Photon Microscopy of 5-Hydroxytryptamine Autofluorescence. Biophysical Journal, 1999. 76: p. 1835-1846.

Bago, B., W. Zipfel, R.M. Williams, and Y. Piche, Nuclei of symbiotic arbuscular mycorrhizal fungi as revealed by in vivo two-photon microscopy. Protoplasma, 1999. 209(1-2): p. 77-89.

Brown, E.B., E.S. Wu, W. Zipfel, and W.W. Webb, Measurement of molecular diffusion in solution by multiphoton fluorescence photobleaching recovery. Biophysical Journal, 1999. 77(5): p. 2837-2849.

Caylor, C.L., I. Dobrianov, C. Kimmer, R.E. Thorne, W. Zipfel, and W.W. Webb, Two-photon fluorescence imaging of impurity distributions in protein crystals. Physical Review E, 1999. 59(4): p. 3831-3834.

Caylor, C.L., I. Dobrianov, S.G. Lemay, C. Kimmer, S. Kriminski, K.D. Finkelstein, W. Zipfel, W.W. Webb, B.R. Thomas, A.A. Chernov, and R.E. Thorne, Macromolecular impurities and disorder in protein crystals. Proteins-Structure Function and Genetics, 1999. 36(3): p. 270-281.

Caylor, C.L., C. Kimmer, I. Dobrianov, K.D. Finkelstein, W. Zipfel, W.W. Webb, and R.E. Thorne, The spatial distribution of impurities in protein crystals and associated impurity effects. Biophysical Journal, 1999. 76(1): p. A350-A350.

Williams, R.M., J.B. Shear, W.R. Zipfel, S. Maiti, and W.W. Webb, Mucosal mast cell secretion processes imaged using three-photon microscopy of 5-hydroxytryptamine autofluorescence. Biophysical Journal, 1999. 76(4): p. 1835-1846.

1998

Bago, B., W. Zipfel, R.M. Williams, H. Chamberland, J.G. Lafontaine, W.W. Webb, and Y. Piche, In vivo studies on the nuclear behavior of the arbuscular mycorrhizal fungus Gigaspora rosea grown under axenic conditions. Protoplasma, 1998. 203(1-2): p. 1-15.

1997

Kohler, R.H., J. Cao, W.R. Zipfel, W.W. Webb, and M.R. Hanson, Exchange of protein molecules through connections between higher plant plastids. Science, 1997. 276(5321): p. 2039-2042.

Kohler, R.H., W.R. Zipfel, W.W. Webb, and M.R. Hanson. The green fluorescent protein as a marker to visualize plant mitochondria in vivo. Plant Journal, 1997. 11(3): p. 613-621.

Maiti, S., J.B. Shear, R.M. Williams, W.R. Zipfel, and W.W. Webb, Measuring serotonin distribution in live cells with three-photon excitation. Science, 1997. 275(5299): p. 530-532.

1996

Xu, C., R.M. Williams, W. Zipfel, and W.W. Webb, Multiphoton excitation cross-sections of molecular fluorophores. Bioimaging, 1996. 4(3): p. 198-207.

Xu, C., W. Zipfel, J.B. Shear, R.M. Williams, and W.W. Webb, Multiphoton fluorescence excitation: New spectral windows for biological nonlinear microscopy. Proceedings of the National Academy of Sciences of the United States of America, 1996. 93(20): p. 10763-10768.

1987-1995 

Laible, P.D., W. Zipfel, and T.G. Owens, Excited-State Dynamics in Chlorophyll-Based Antennae - The Role of Transfer Equilibrium. Biophysical Journal, 1994. 66(3): p. 844-860.

Lee, J.W., W. Zipfel, and T.G. Owens, Quenching of Chlorophyll Excited-States in Photosystem-I By Quinones - Stern-Volmer Analysis of Fluorescence and Photochemical Yield. Journal of Luminescence, 1992. 51(1-3): p. 79-89.

Zipfel, W. and T.G. Owens, Calculation of Absolute Photosystem-I Absorption Cross-Sections from P700 Photooxidation Kinetics. Photosynthesis Research, 1991. 29(1): p. 23-35.

Zipfel, W.R., R.G. Alscher, and L. Zucker, Effects of Sulfite on Phosphoenolpyruvate Carboxylase and Nicotinamide Adenine-Dinucleotide Phosphate-Dependent Malate-Dehydrogenase In Epidermal Peels. Physiologia Plantarum, 1990. 79(3): p. 491-496.

Alscher, R., J.L. Bower, and W. Zipfel, The Basis for Different Sensitivities of Photosynthesis to sulfur dioxide. Journal of Experimental Botany, 1987. 38(186): p. 99-108.

Book Chapters

Bacskai BJ, Kajdasz ST, Christie RH, Zipfel WR, Williams RM, Kasischke KA, Webb WW, Hyman BT. Chronic imaging of amyloid plaques in the live mouse brain using multiphoton microscopy. In: Periasamy A, So PTC, editors. Multiphoton Microscopy in the Biomedical Sciences. Proceedings of the Society of Photo-Optical Instrumentation Engineers (SPIE). 22001. p. 125-33.

Zipfel WR, Webb WW. In vivo diffusion measurements using multiphoton excitation fluorescence photobleaching recovery and fluorescence correlation spectroscopy.  Methods in Cellular Imaging: Springer; 2001. p. 216-35.

Flesken-Nikitin A, Williams RM, Zipfel WR, Webb WW, Nikitin AY. Use of multiphoton imaging for studying cell migration in the mouse. In: Guan JL, editor. Methods in Molecular Biology. Methods in Molecular Biology. 2942004. p. 335-45.

Yao J, Larson DR, Zipfel WR, Webb WW. Dark fraction and blinking of water-soluble quantum dots in solution. In: Cartwright AN, Osinski M, editors. Nanobiophotonics and Biomedical Applications II. Proceedings of the Society of Photo-Optical Instrumentation Engineers (SPIE). 57052005. p. 148-51.

Xu C, Zipfel WR. Multiphoton excitation of fluorescent probes.  Cold Spring Harbor protocols. 20152015. p. pdb.top086116-pdb.top.

Colville M, Park S, Singh A, Paszek M, Zipfel WR. Azimuthal Beam Scanning Microscope Design and Implementation for Axial Localization with Scanning Angle Interference Microscopy. In: Avraham Rasooly P, Miguel R. Ossandon , PhD, and Houston Baker, PhD editor. Bioengineering Technologies: Humana Press; 2020.

Converted to HTML with WordToHTML.net | Document Converter for Windows