Developmental
Resource
for Biophysical Imaging
Opto-Electronics
An
NIH-NIBIB Biomedical Technology Resource
School
of Applied and Engineering Physics, College
of Engineering
Welcome
to the home of FCS and MPM.
News! | Maps | Links | Biophysics
Colloquia | Group
Info | Jobs!
Home
People (Contacts)
DRBIO
Pubs (Dissemination)
Watt W. Webb
Pubs (Dissemination)
Biophysical
Research
Multiphoton Microscopy, Visible
MPM Mouse, Nanodevices:
Nanofluidics
and Excitation Confinement Strategies, Dynamic Spectroscopies
Infrastructure
Development
...Fluorescent
Probes, Dynamic Spectroscopies, Nonlinear
Microscopies, A
'Typical' Multiphoton Microscope
Collaborate
Image
above relates to Park,
H.Y., S. A. Kim, J. Korlach, E. Rhoades, L.W. Kwok, W.R. Zipfel, M.N.
Waxham, W.W. Webb, and L. Pollack, “Conformational
changes of calmodulin upon Ca2+-binding studied with a microfluidic
mixer,” PNAS 105(2), 542-547, 2008.
Apo-calmodulin (lower left) binds four calcium ions,
and undergoes large conformational changes (lower right). Park et al.
have applied a microfluidic mixer in conjunction with multiphoton microscopy
to study the fast conformational changes of calmodulin upon Ca2+-binding.
The microfluidic device enables measurements of rapid kinetics with
~40 microsecond time resolution.
Image courtesy of Hye Yoon Park.
Go to previous DRBIO homepage
images.
National
Institute on Aging
Copyright ©2006-2008, DRBIO, Cornell University. Site developed using grants listed on our Funding page.
E-Mail for Information. E-Mail Webmaster M. Williams. E-mail Technical Advisor R. Williams. Last update: April 9, 2008.
