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Biography
Education:
University
Of Minnesota, Minneapolis, B.E.D., 1987, Architecture
University Of Minnesota, Minneapolis, B.S., 1987, Physics
Cornell University, Ithaca, NY, M.S., 1992, Physics
Cornell University, Ithaca, NY, Ph.D., 1997, Physics
Research and professional experience:
1987-1988 Research Specialist, Regional Daylighting
1989-1990 Teaching Assistant, Physics, Cornell University
1990-1993 Research Physicist, 3M Company, Minneapolis, MN
1990-1991 Teaching Assistant, Physics, Cornell University
1991-1997 Graduate Research Assistant, Applied Physics, Cornell
University
1997-present Research Associate, Applied Physics, Cornell University
Selected publications in chronological order:
Williams, R. M., D. W. Piston and W. W. Webb (1994). "2-Photon
Molecular-Excitation Provides Intrinsic 3-Dimensional Resolution
for Laser-Based Microscopy and Microphotochemistry." Faseb
Journal 8(11): 804-813.
Sandison, D. R., D. W. Piston, R. M. Williams and W. W. Webb (1995).
"Quantitative Comparison of Background Rejection, Signal-to-
Noise Ratio, and Resolution in Confocal and Full-Field Laser- Scanning
Microscopes." Applied Optics 34(19): 3576-3588.
Sandison, D. R., R. M. Williams, K. S. Wells, J. Strickler and W.
W. Webb (1995). Quantitative Fluorescence Confocal Laser Scanning
Microscopy. Handbook of Biological Confocal Microscopy. J. Pawley:
39-53.
Xu, C., R. M. Williams, W. R. Zipfel and W. W. Webb (1996). "Multiphoton
Excitation Cross-Sections of Molecular Fluorophores." Bioimaging
4(3): 198-207.
Xu, C., W. Zipfel, J. B. Shear, R. M. Williams and W. W. Webb (1996).
"Multiphoton fluorescence excitation: New spectral windows
for biological nonlinear microscopy." PNAS 93(20): 10763-10768.
Maiti, S., J. B. Shear, R. M. Williams, W. R. Zipfel and W. W. Webb
(1997). "Measuring serotonin distribution in live cells with
three- photon excitation." Science 275(5299): 530-532.
Xu, K., R. M. Williams, D. Holowka and B. Baird (1998). "Stimulated
release of fluorescently labeled IgE fragments that efficiently
accumulate in secretory granules after endocytosis in RBL-2H3 mast
cells." Journal of Cell Science 111: 2385-2396.
Bago, B., W. Zipfel, R. M. Williams, H. Chamberland, J. G. Lafontaine,
W. W. Webb and Y. Piche (1998). "In vivo studies on the nuclear
behavior of the arbuscular mycorrhizal fungus Gigaspora rosea grown
under axenic conditions." Protoplasma 203(1-2): 1-15.
Williams, R. M., J. B. Shear, W. R. Zipfel, S. Maiti and W. W. Webb
(1999). "Mucosal mast cell secretion processes imaged using
three-photon microscopy of 5-hydroxytryptamine autofluorescence."
Biophys J 76(4): 1835-1846.
Williams, R. M. and W. W. Webb (2000). "Single granule pH cycling
in antigen-induced mast cell secretion." J Cell Sci 113(21):
3839-3850.
Williams, R. M., W. R. Zipfel and W. W. Webb (2001). "Multiphoton
microscopy in biological research." Curr Opin Chem Biol 5(5):
603-8.
Christie, R. H., B. J. Bacskai, W. R. Zipfel, R. M. Williams, S.
T. Kajdasz, W. W. Webb and B. T. Hyman (2001). "Growth arrest
of individual senile plaques in a model of Alzheimer’s disease
observed by in vivo multiphoton microscopy." Journal of Neuroscience
21(3): 858–864.
Bago, B., W. Zipfel, R. M. Williams, J. Jun, R. Arreola, P. J. Lammers,
P. E. Pfeffer and Y. Shachar-Hill (2002). "Translocation and
Utilization of Fungal Storage Lipid in the Arbuscular Mycorrhizal
Symbiosis." Plant Physiology 128: 108-124.
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