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Visualization and Perturbation of Cortical Circuit Assembly In Vivo
Eric C. Olson, Assistant Professor of Neuroscience, SUNY Upstate Medical University, Syracuse, NY.

In the developing cerebral cortex, most neurons migrate along radial glial fibers until reaching their destination, where they transition to non-mobile cells that elaborate dendrites. Existing models suggest that neuronal migration and dendritogenesis are distinct events, with brain wiring following migration arrest. The objective of this project is to visualize the incorporation of migrating neurons into their assembling cortical circuit in a series of in vivo imaging experiments. 

References

Olson EC, Kim S, Walsh CA (2006) Impaired neuronal positioning and dendritogenesis in the neocortex after cell-autonomous Dab1 suppression. J Neurosci 26:1767-1775.

 

 

 



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