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An NIH-NIBIB Biomedical Technology Resource





Major collaborations (alphabetical order)
These 7 collaborative projects are the primary drivers of our technology development efforts:

(FarnumIn Vivo Visualization of Long Bone Growth
Cornelia E. Farnum, Biomedical Sciences, Cornell Veterinary School.
William Horton, Professor of Molecular and Medical Genetics, Oregon Health & Science University.
Funding: NIH R01AR052003 in Vivo Imaging of Growth Plate Dynamics (3/2005-2/2010).

(FlynnGenetically Encodeable Reporters of Bacterial Status in Tuberculosis
Joanne Flynn, Professor of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine.
David Russell, Microbiology and Immunology, Cornell University.
Funding: Bill and Melinda Gates Foundation, Accelerator Grant Program.

(FortierITE-MPM for Cartilage Diagnostics
Lisa A. Fortier, Assistant Professor of Surgery, Department of Clinical Sciences, Cornell University.
Hollis G. Potter, MD, Chief of Resonance Imaging, Hospital for Special Surgery.
Funding: The Stowe Foundation (7/06-6/10).

(Hyman Nanofluidic Devices for Studying Early Aggregation Properties of Beta-Amyloid and Alpha-Synuclein
Bradley T. Hyman, Professor of Neuroscience, Harvard University.
Pamela J. McLean, Assistant Professor of Neurology, Harvard University.
Funding: P50 NS038372-08 (Project 1) (9/30/98 – 8/31/09), R01 AG008487-17 (8/89-8/11).

(NathansonMultiphoton Endoscopy for Diagnosis of Barrett’s Esophagus
Michael Nathanson, Section Chief of Digestive Diseases, Internal Medicine, Yale University School of Medicine.
Funding: P30 DK34989, R01 DK45710 (01/01/95-03/31/10).

(NikitinStudies On the Progression and Detection of Cancer in Transgenic Mouse Models
Alexander Nikitin, Associate Professor of Biomedical Sciences, Cornell University.
Funding: R01 CA116583 (07/01/05-06/31/10).

(Webb/WeillDevelopment of Medical Mutiphoton Microscopic Endoscopy
Watt W. Webb (PI) Professor of Applied and Engineering Physics, Cornell University.
Weill Medical College, New York, NY:
Fahey, Thomas J., Co-I, Associate Professor of Surgery
Maxfield, Frederick R., Co-I, Chair, Department of Biochemistry
Milsom, Jeffrey W., Co-I, Professor of Surgery
Pochapin, Mark B., Co-I, Chief, Division of Gastrointestinal Endoscopy
Scherr, Douglas S., Co-I, Assistant Professor of Urology
Tewari, Ashutosh K., Co-I, Associate Professor of Urology
Funding: NIH/NIBIB R01-EB006736  Development of Medical Multiphoton Microscopic Endoscopy (6/07-3/12)

Other collaborations (alphabetical order):

(AndrewLive Imaging of Epithelial Development in Mutant Drosophila Embryos
Deborah Andrew, Cell Biology and Biomedical Engineering, Johns Hopkins School of Medicine.
Funding: R01DE12873 (01/02/99-06/30/09) R01DE13899 (02/01/01 – 04/31/11).

(GourasCharacterization of Microtubule Polarity in Mouse Alzheimer’s Disease Models
Gunnar Gouras, Associate Professor of Neurology and Neuroscience, Weill Cornell Medical.
Funding: NIH NIA 5R01AG027140 Intraneuronal Abeta accumulation: mechanism of pathogenesis (8/1/07-4/30/11).

(Harris-WarrickImaging the Spinal Neural Circuits During Fictive Locomotion
Ronald M. Harris-Warrick, Professor of Neurobiology and Behavior, Cornell University.
Funding: NINDS R01 R37NS017323 Neurotransmitters, Neuromodulators and Motor Systems (4/81-12/09).

(KloppenburgModulation of Synaptic Properties in Central Pattern Generator Neuronal Networks
Peter Kloppenburg, Professor of Cellular Neurophysiology, Universität zu Köln.
Ronald M. Harris-Warrick, Professor of Neurobiology and Behavior, Cornell University.
Funding: NINDS R37 NS17323-21 (1/1/06-12/31/12).

(KotlikoffNew Probes for In Vivo Imaging of Cell-Cell Signaling
Michael Kotlikoff, Biomedical Sciences, Cornell University.
Funding: NIH R01DK07227 (03/01/06-06/30/11).

(Lis1. Mechanisms of Eukaryotic Transcription by MPM imaging of Drosophila Polytene Nuclei
          2. RNA Aptamer-based Probes for Intracellular Targeting
John T. Lis, Professor of Molecular Biology and Genetics, Cornell University.
Funding: NIH-GM25232 (04/01/78-03/31/14), T32-GM00727 (07/01/75-06/30/11).

(LohExploring Protein Intramolecular Contact Rates and Protein Folding
Stewart N. Loh, Associate Professor of Biochemistry and Molecular Biology, SUNY Upstate Medical University.
Funding: NIH/NIGMS 5R01GM069755-04  Mutually exclusive protein folding (12/03-7/09).

(OberMeasurements On the Dye AF240 Solublized By b-Cyclodextrin
Christopher Ober, Professor of Department of Materials Science, Cornell University.
Funding: NSF ECS-9876771 Cornell Nanobiotechnology Center.

(PistonCharacterization of New Fluorescent Proteins (FPs)
David Piston, Professor of Molecular Physiology and Biophysics, Professor of Physics, Vanderbilt University.
Funding: NIH NCI P20 GM72048 (8/04-7/08), R01 DK53434 (1/98-11/10).

(RhoadesMeasuring Alpha-Synuclein Conformational Dynamics Using FCS
Elizabeth Rhoades, Assistant Professor of Molecular Biophysics & Biochemistry, Yale University.
David Eliezer, Associate Professor of Biochemistry, Weill Medical College.
Funding: NIH/NIGMS 1R21GM084391 Conformations and dynamics of amyloid-induced membrane disruption (5/08-4/10).

(SchmehlCharacterization of a New Oxygen Sensing Probe for Multiphoton Use
Russell Schmehl, Professor of Chemistry, Tulane University.

(Wiesner)  Characterization and Application of Fluorescent Silica Nanoparticles (C dots)
Ulrich Wiesner, Professor of Materials Science, Cornell University.
Funding:  NSF through the Cornell Center for Material Research (CCMR).

New collaborations (alphabetical order)

(CohenUse of SHG Imaging and Elastography to Characterize Heterogeneities in Cartilage Mechanics
Itai Cohen, Assistant Professor of Physics, Cornell University.

(Fischbach-TeschlAnalysis of Tumor Angiogenesis As Regulated by Soluble Microenvironmental Cues
Claudia Fischbach-Teschl, Assistant Professor of Biomedical Engineering, Cornell University.
Funding: NYSCAT Innovation grant (07/07 – 06/010).

(JacenkoUse of Multiphoton Imaging To Test Whether the Mechanism of Aberrant Endochondral Ossification (EO) in Hypomorphic Perlecan C1532Yneo Mice Leading To Avascular Necrosis (AVN) Is Due To Delayed Or Disrupted Vascularization
Olena Jacenko, Associate Professor of Animal Biology, Univ of Pennsylvania School of Veterinary Medicine.
Funding: NIH/NIDDK DK057904-09 Mechanisms of skeleto-hematopoietic differentiation (4/04 – 3/10).

(MaherEvaluation of Implanted Cartilage Repair Scaffolds
Suzanne Maher, Assistant Scientist, Hospital for Special Surgery, NYC.
Funding: Arthritis Foundation: A Novel Hydrogel for Focal Cartilage Defect Repair (7/06- 6/09).

(OlsonVisualization and Perturbation of Cortical Circuit Assembly In Vivo
Eric C. Olson, Assistant Professor of Neuroscience, SUNY Upstate Medical University, Syracuse, NY.

(SchwartzEvaluation of Multiphoton Imaging for Analyzing the Nature and Distribution of Advanced Glycation Endproducts (AGE’s) in Diabetic Skin
Suzanne Schwartz, Assistant Professor, Department of Surgery, Weill Medical College of Cornell.
Funding: NIH/NIGMS 1K23GM073728-01 Impact of Diabetes upon Burn Injury (4/05-3/10).

Collaborative partners in industry

Hamamatsu: New photodetectors for MPM and other fluorescence applications.

Zeiss Microimaging:  Multiphoton microscopy developement.

Olympus:  Multiphoton microscopy developement.

OFS Laboratories (Murray Hill, New Jersey): HOM fiber laser development (see Core R&D project 2)

Crysta-lyn Chemical Company: Fluorophore development.




: Lab Schedule

: Group Presentations

: Protocols

- Biomedical Engineering
- Applied & Eng. Physics
- College of Engineering
- Cornell University

- Bio-Imaging Seminar
- Biophysics Seminar

- MPM Documentation
- DRBIO Subversion


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