In vivo imaging of transgenic mouse models
for Alzheimer's Disease

For obvious reasons, very little is known about how amyloid aggregates develop in Alzheimer's Disease. The Hyman lab has developed a method for multiphoton imaging in mouse models for Alzheimers disease. The skull is thinned and a standard histological dye is introduced by syringe. Individual plaques can be followed with micron resolution over a time-course of months.

Christie, R. H., Bacskai, B. J., Zipfel, W. R., Williams, R. M., Kajdasz, S. T., Webb, W. W. & Hyman, B. T. (2001) Journal of Neuroscience 21, 858–864.