Abstract Signaling
photoreceptors may be classified by the nature of their chromophore
(e.g. retinal, p-coumaric acid, FMN, FAD, bilin, heme), the nature
of their initial photochemistry (isomerization, formation or rupture
of a covalent bond, electron transfer), and the structures of their
sensor (input) and effector (output) domains. How does absorption
of a photon by the chromophore produce structural changes that propagate
across the sensor domain? How are these transferred either inter-
or intramolecularly to the sensor domain? How is the activity of
the effector domain thereby modulated? Are there general principles
of signal generation and transduction, or is each photoreceptor unique?
In short, how does signaling work, at the atomic level? |